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C-reactive protein, apolipoprotein A-I, lipoprotein (a), and oxidized LDL as prognostic risk factors in diabetic and nondiabetic patients with heart disease.
The objective of the study was to investigate the prognostic value of C-reactive protein (CRP), lipoprotein (a) (Lp(a)), apolipoprotein (apo) A-I, and oxidized low-density lipoprotein (oxLDL) in patients with heart disease. Prospective study including a total of 1,166 patients from the outpatient clinic of the department of cardiology of the Reinier de Graaf Hospital, Delft. During 5 years follow-up, 255 patients (21.9%) died of all causes, and 79 patients (6.8%) had a myocardial infarction. Patients with an initial CRP value above 1 mg/L and patients with high Lp(a) values had a significantly increased risk of all-cause mortality in comparison with patients with low values (CRP and Lp(a), respectively). Patients with high Lp(a) and low apoA-I levels had a significantly increased risk of all-cause mortality in comparison with patients with low Lp(a) and low apoA-I levels. Patients with high Lp(a) and high apoA-I levels had a significantly increased risk of myocardial infarction. Using a CRP level of 1 mg/L, an Lp(a) level of 5 mg/dL, and an apoA-I level of 1.05 g/L, it was possible to predict the 5-year risk of mortality in patients with ischemic heart disease (area under the curve 0.75, p = 0.001) and of myocardial infarction (area under the curve 0.74, p = 0.02).Pope Francis called for a “culture of encounter” to combat “imagineering” in the West and the “spirit of globalization” in Africa and Asia.
In his message for the opening of the 7th Ordinary Assembly of the Synod of Bishops for the Pan-Amazon be359ba680
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